KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance
A. M. Zavitsanou, Y. Hao, W. L. Wu, E. Bartnicki, R. Pillai, T. Karakousi, A. Herrera, A. Karatza, A. Rashidfarrokhi, S. Solis, M. Ciampricotti, A. H. Yeaton, E. Ivanova, C. A. Wohlhieter, T. B. Buus, , S. B. Koralov
This study shows KEAP1 mutations in lung adenocarcinoma lead to immune evasion by reducing dendritic cell and T cell responses, contributing to immunotherapy resistance.
bioRxiv · Sep 24, 2021 · PreprintCancer Biology