Y. Hao

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Regulation of Kv1.2 redox-sensitive gating by the transmembrane lectin LMAN2

This study identifies LMAN2 as a regulatory protein that modulates redox-sensitive gating of Kv1.2 channels by altering activation kinetics and redox sensitivity.

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

An epilepsy-associated CILK1 variant compromises KATNIP regulation and impairs primary cilia and Hedgehog signaling

This study shows that a CILK1 variant linked to epilepsy impairs primary cilia and Hedgehog signaling by disrupting KATNIP regulation in mouse cells.

Compartmental Differences in the Retinal Ganglion Cell Mitochondrial Proteome

The paper identifies compartment-specific mitochondrial proteins in retinal ganglion cells using mass spectrometry and immunofluorescence validation.

Virtual Growing Child (VGC): A general normative comparative system via quantitative dynamic MRI for quantifying pediatric regional respiratory anomalies with application in thoracic insufficiency syndrome (TIS)

The paper introduces VGC, a normative database for pediatric respiratory measurements using MRI, to quantify regional respiratory anomalies in thoracic insufficiency syndrome patients.

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

The paper discovers synthetic antibodies specific to RGD-binding integrins and identifies their subunit pairing preferences.

Late consolidation of rRNA structure during co-transcriptional assembly in E. coli by time-resolved DMS footprinting

This study uses time-resolved DMS footprinting to show that rRNA tertiary interactions and protein binding sites in E. coli remain unfolded until late stages of ribosome assembly.

Adaptive immunity: from CRISPR to CRIHSP?

The paper identifies CRIHSP structures in human adaptive immunity genes, showing their association with genomic instability and recombination.

O-GlcNAcylation of Keratin 18 coordinates TCA cycle to promote cholangiocarcinoma progression

The paper shows O-GlcNAcylation of Keratin 18 coordinates TCA cycle enzymes to promote cholangiocarcinoma progression by stabilizing K18 and altering metabolite levels.

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth

This study identifies a LKB1-LIF signaling axis in tumors that promotes immune evasion by reprogramming myeloid cells, and shows that inhibiting LIF signaling reduces tumor growth.

miR-324 mediates bone homeostasis through the regulation of osteoblast and osteoclast differentiation and activity

This study shows miR-324 regulates bone homeostasis by controlling osteoblast and osteoclast activity, with its deletion causing increased bone mass and cartilage damage in OA and aging.

ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims

This study shows that ROM1 can be replaced by increased PRPH2 levels to restore normal photoreceptor disc structure in knockout mice.

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

This study shows that DRP-104, a glutamine antagonist, suppresses KEAP1 mutant lung tumor growth and enhances response to checkpoint blockade by inhibiting glutamine metabolism and improving T cell function.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1-mutant lung cancer

The paper identifies CD38 as a therapeutic target in LKB1-mutant lung cancer through in vivo metabolomics and shows that targeting CD38 inhibits tumor growth.

Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure

This study shows incisures in photoreceptor discs form after complete enclosure and are regulated by the ratio of peripherin-2 to rhodopsin.

Single-Cell Map of Dynamic Multicellular Ecosystem of Radiation-Induced Intestinal Injury

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

Pioneer factor Foxa2 mediates chromatin conformation changes in ligand-dependent activation of nuclear receptor FXR

The paper shows Foxa2 enables chromatin conformation changes during FXR ligand activation in mouse livers, increasing long-range interactions and altering TADs and loops.

Image-based Flow Simulation of Platelet Aggregates under Different Shear Rates

This paper presents an image-based computational model to simulate blood flow around platelet aggregates under varying shear rates, showing that agonist transport and kinetic forces depend on both shear rate and aggregate microstructure.

Gene expression plasticity followed by genetic change during colonization a high-elevation environment

The paper quantifies gene expression plasticity and genetic change in Eurasian Tree Sparrows during high-elevation colonization, showing plasticity is often reversed or reinforced through selection.

Serial Capture Affinity Purification and Integrated Structural Modeling of the H3K4me3 Binding and DNA Damage Related WDR76:SPIN1 Complex

The paper uses SCAP to isolate the WDR76:SPIN1 complex, identifies H3K4me3 binding, and shows its role in DNA damage response through structural modeling and interaction network analysis.

Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB via DNMT3b-mediated DNA hypomethylation

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.

Regulation of interstitial fluid flow along adventitia of vasculature by heartbeat and respiration

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

KNOWLEDGE GRAPH AIDS COMPREHENSIVE EXPLANATION OF DRUG TOXICITY

AIDTox is an interpretable deep learning model that predicts cytotoxicity and explains drug toxicity mechanisms using curated biological knowledge.

Continuous Hypoxia Reduces Retinal Ganglion Cell Degeneration in a Mouse Model of Mitochondrial Optic Neuropathy

This study shows that continuous hypoxia rescues retinal ganglion cell degeneration in a mouse model of mitochondrial optic neuropathy, though the effect is not sustained at later time points.

Function and structure of FlaK, a master regulator of the polar flagellar genes in marine Vibrio

This study investigates FlaK's role in regulating flagellar gene expression in Vibrio alginolyticus through mutational analysis and biochemical assays, revealing its ATPase activity and interactions with FlhG.

ZetaSuite, A Computational Method for Analyzing Multi-dimensional High-throughput Data, Reveals Genes with Opposite Roles in Cancer Dependency

ZetaSuite analyzes multi-dimensional high-throughput data to identify genes with opposite roles in cancer dependency, revealing key genes in DNA replication/repair checkpoint.

Subtype-specific single β1 integrin mechanics for activation, mechanotransduction and cytoskeleton remodeling

The paper investigates subtype-specific mechanics of β1 integrins in cell spreading, showing different tension thresholds and cytoskeletal remodeling for integrin α4β1 versus RGD-binding integrins.

Formation of multiple flagella caused by a mutation of the flagellar rotor protein FliM in Vibrio alginolyticus

This study identifies an E9K mutation in FliM that causes multiple flagella in Vibrio alginolyticus by inhibiting FlhG ATPase activity, revealing a novel regulatory mechanism for flagellar number control.