A. Herrera

EMERGENCE OF OXA-48-LIKE CARBAPENEMASES IN CLINICAL ENTEROBACTERALES FROM GUATEMALA

The paper reports the first detection of OXA-48-like carbapenemase genes in clinical Enterobacterales from Guatemala, indicating their circulation since 2019.

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth

This study identifies a LKB1-LIF signaling axis in tumors that promotes immune evasion by reprogramming myeloid cells, and shows that inhibiting LIF signaling reduces tumor growth.

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

This study shows that DRP-104, a glutamine antagonist, suppresses KEAP1 mutant lung tumor growth and enhances response to checkpoint blockade by inhibiting glutamine metabolism and improving T cell function.

Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy

This study identifies MCF, a Vibrio effector that cleaves and degrades Rab GTPases, disrupting organelle function and promoting cell death during infection.

Evidence for HARKing in mouse behavioural tests of anxiety

The paper examines the use of HARKing in mouse anxiety behavioural tests, finding that test rationale and predicted effects depend on reported results, suggesting post-hoc reasoning.

KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance

This study shows KEAP1 mutations in lung adenocarcinoma lead to immune evasion by reducing dendritic cell and T cell responses, contributing to immunotherapy resistance.

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19

This study compares the antiviral efficacy of PF-00835231, GC-376, and remdesivir in human airway models, showing PF-00835231 is at least as potent as the others and not affected by P-glycoprotein efflux.

Borrelia afzelii does not suppress the development of anti-tick immunity in bank voles

This study shows that Borrelia afzelii does not suppress anti-tick immunity in bank voles, which negatively affects tick fitness and reduces pathogen transmission.

N-terminal autoprocessing and acetylation of MARTX Makes-Caterpillars Floppy-like effector is stimulated by ADP-Ribosylation Factor 1 in advance of Golgi fragmentation

This study identifies ARF1 and ARF3 as activators of MCF autoprocessing and shows that MCF acetylation and Golgi fragmentation contribute to cytotoxicity.

β-Catenin tumour-suppressor activity depends on its ability to promote Pro-N-Cadherin maturation

This study shows that β-Catenin promotes Pro-N-Cadherin maturation, which is necessary for apical junction formation and apico-basal polarity, and that this activity suppresses tumor formation in neural stem cells.

Ethnobotanical and nutritional study of quelites sold in two traditional markets of Oaxaca, Mexico

The paper studies quelites sold in two Oaxaca markets, finding that flower-based species are rich in proteins, bioactive compounds, and minerals, suggesting their potential as dietary alternatives.

PI3K regulates intraepithelial cell positioning through Rho GTP-ases in the developing neural tube.

This study shows PI3K regulates intraepithelial cell positioning via Rho GTPases in the developing neural tube and links its activation to cell invasion in tumors.