Author

A. Kirchhoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

A. K. de Regt· 2 shared E. Bartok· 2 shared G. Hartmann· 2 shared K. Ciupka· 2 shared M. Geyer· 2 shared M. Schlee· 2 shared A. Gruenewald· 1 shared A. Grünewald· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

A. K. de Regt

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2 papers

Recent·Most cited

hnRNPM and ELAVL1 control type I interferon induction by promoting IRF3 phosphorylation downstream of both cGAS and RIG-I

A. Kirchhoff, A.-M. Herzner, C. Urban, A. Piras, R. Düster, J. Wegner, A. Grünewald, T. M. Schlee-Guimaraes, K. Ciupka, P. Leka, R. J. Bootz, A. K. de Regt, B. Kümmerer, M. Honholt Christensen, F. I. Schmidt, , M. Schlee

bioRxiv · Jun 23, 2023 · PreprintImmunology

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

A. K. de Regt, K. Anand, K. Ciupka, K. Gatterdam, B. Putschli, D. Fusshoeller, D. Hilbig, A. Kirchhoff, C. Hunkler, S. Wolter, A. Gruenewald, C. Schuberth-Wagner, J. Ludwig, K. Paeschke, E. Bartok, , M. Schlee

This study identifies an isoleucine residue in RIG-I that prevents recognition of 5p-RNA, thereby maintaining immune tolerance to mitochondrial RNA.

bioRxiv · Aug 2, 2022Immunology