Author

J. Ludwig

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. B. Hartono· 1 shared A. G. Mikos· 1 shared A. Ghosh· 1 shared A. Gruenewald· 1 shared A. K. de Regt· 1 shared A. Kirchhoff· 1 shared A. Tannenbaum· 1 shared B. L. King· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

A. B. Hartono

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enzalutamide Induces Cytotoxicity in Desmoplastic Small Round Cell Tumor Independent of the Androgen Receptor

J. W. Magrath, I. N. Goldberg, D. T. Truong, A. B. Hartono, S. S. Sampath, C. E. Jackson, A. Ghosh, D. Cardin, H. Zhang, J. Ludwig, S. Lee

The paper shows enzalutamide reduces DSRCT growth independently of AR, challenging the hypothesis that AR drives male predominance in this cancer.

bioRxiv · Nov 6, 2023Cancer Biology

Mapping the Single-cell Differentiation Landscape of Osteosarcoma

D. D. Truong, C. Weistuch, K. A. Murgas, P. Admane, B. L. King, J. Chauviere Lee, S.-E. Lamhamedi-Cherradi, J. Swaminathan, N. C. Daw, N. Gordon, V. Gopalakrishnan, R. G. Gorlick, N. Somaiah, J. O. Deasy, A. G. Mikos, , J. Ludwig

The paper maps the differentiation landscape of osteosarcoma using single-cell data to identify gene modules linked to cell fate and patient survival.

bioRxiv · Sep 13, 2023Cancer Biology

Targeting plasma membrane and mitochondrial instability in breast cancer cells and breast epithelial to mesenchymal transition-model cells by adamantyl diaza-crown ether ZG613

K. Ester, M. Mioc, P. Spurny, D. Bonhenry, M. Marjanovic, L. Uzelac, J. Gabrilo, T. Sumanovac, W. Schreibmayer, K. Majerski, B. Minofar, J. Ludwig, M. Kralj

This study evaluates ZG613's ability to disrupt plasma membranes and mitochondria in breast cancer and EMT-model cells, showing reduced tumor growth in vivo.

bioRxiv · Sep 30, 2022 · PreprintCancer Biology

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

A. K. de Regt, K. Anand, K. Ciupka, K. Gatterdam, B. Putschli, D. Fusshoeller, D. Hilbig, A. Kirchhoff, C. Hunkler, S. Wolter, A. Gruenewald, C. Schuberth-Wagner, J. Ludwig, K. Paeschke, E. Bartok, , M. Schlee

This study identifies an isoleucine residue in RIG-I that prevents recognition of 5p-RNA, thereby maintaining immune tolerance to mitochondrial RNA.

bioRxiv · Aug 2, 2022Immunology