ImmunologybioRxiv
A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA
A. K. de Regt, K. Anand, K. Ciupka…·M. Schlee
This study identifies an isoleucine residue in RIG-I that prevents recognition of 5p-RNA, thereby maintaining immune tolerance to mitochondrial RNA.
DOI 10.1093/nar/gkad835