BiochemistrybioRxiv
An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
P. Kaya, E. Schaffner-Reckinger, G. B. Manoharan…·D. K. Abankwa
The paper develops a novel PDE6D inhibitor, Deltaflexin3, which synergizes with Sildenafil to inhibit KRAS mutant cancer cell growth, though survival data suggest further exploration of K-Ras and PDE6D interplay.
DOI 10.1021/acs.jmedchem.3c02129