Residual Complex I activity supports glutamate catabolism and mtSLP via canonical Krebs cycle activity during acute anoxia without OXPHOS
D. Ravasz, D. Bui, S. Nazarian, G. Pallag, N. Karnok, J. Roberts, D. A. Tennant, B. Greenwood, A. Kitayev, C. Hill, T. Komlodi, C. Doerrier, E. Gnaiger, M. A. Kiebish, A. Raska, , C. Chinopoulos
The paper shows that residual Complex I activity sustains glutamate catabolism and mtSLP during acute anoxia by oxidizing NADH with endogenous quinones, bypassing OXPHOS.
bioRxiv · Sep 26, 2022 · PreprintBiochemistry