C. Hill

The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly

The paper presents structures of AFPKs from Elysia chlorotica, revealing the ACP linker's role in regulating substrate and product selectivity during polyketide and fatty acid synthesis.

NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors

This study identifies NAB2-STAT6 as a driver of a neuroendocrine program in SFTs through its role in enhancing EGR1 target gene expression.

Mother-Infant Gut Viruses and their Bacterial Hosts: Transmission Patterns and Dynamics during Pregnancy and Early Life

Ultrastructure of the nebenkern during spermatogenesis in the praying mantid Hierodula membranacea

The paper uses high-pressure freezing and TEM to study the ultrastructure of sperm development in the praying mantid Hierodula membranacea, revealing the 3D structure of the nebenkern.

Residual Complex I activity supports glutamate catabolism and mtSLP via canonical Krebs cycle activity during acute anoxia without OXPHOS

The paper shows that residual Complex I activity sustains glutamate catabolism and mtSLP during acute anoxia by oxidizing NADH with endogenous quinones, bypassing OXPHOS.

An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors

The paper shows that AIEC synergizes with NSAID to worsen colitis in IL10 -/- mice, which is blocked by NLRP3 and Caspase-8 inhibitors.

T cell Egress via Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma

The paper shows that T cell egress via lymphatic vessels limits intratumoral T cell diversity, and that CXCR4 inhibition enhances T cell retention and improves immunotherapy response.

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and represents a therapeutic target in myelofibrosis

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.

Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson's disease

This study shows that alpha-synuclein treatment in rats alters their faecal virome, with changes persisting over five months and influenced by LPS.

Simons Collaborative Marine Atlas Project (Simons CMAP): an open-source portal to share, visualize and analyze ocean data

Simons CMAP provides an open-source portal to integrate and analyze diverse ocean data for cross-disciplinary studies.

REPEATED INJURY PROMOTES TRACHEOBRONCHIAL TISSUE STEM CELL ATTRITION

This study shows repeated injury depletes tracheobronchial tissue stem cells, leading to abnormal repair and chronic lung disease.

Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis

The paper shows that phase variation in Bacteroides intestinalis capsular polysaccharides enables long-term phage persistence through dynamic resistance and delayed lysis mechanisms.

Microbiome-based environmental monitoring of a dairy processing facility highlights the challenges associated with low microbial-load samples

This study evaluates the effectiveness of MinION and Illumina sequencing for microbial monitoring in a dairy processing facility, finding that MinION provides accurate species-level classification but requires DNA amplification due to high concentration needs.

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.

Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular Events

The paper identifies immune dysregulations in atherosclerotic plaques linked to ischemic cerebrovascular events using single-cell analyses of T cells and macrophages.

The human gut virome is highly diverse, stable and individual-specific

This study characterizes the human gut virome, revealing its high diversity, stability, and individual specificity through longitudinal metagenomic analysis of faecal samples.

Autochthonous faecal virome transplantation (FVT) reshapes the murine microbiome after antibiotic perturbation

This study shows that transplanting an autochthonous faecal virome can reshape the murine microbiome after antibiotic treatment, restoring it closer to its pre-treatment state.

Müllerian mimicry in bumble bees is a transient continuum

The paper uses machine learning to analyze color patterns in bumble bees, finding continuous transitions rather than discrete mimicry complexes.

ΦCrAss001, a member of the most abundant bacteriophage family in the human gut, infects Bacteroides

The paper isolates and characterizes ΦCrAss001, a crAssphage infecting Bacteroides intestinalis, showing its genome structure and replication without lysogeny.

Biology and taxonomy of crAss-like bacteriophages, the most abundant virus in the human gut

This study identifies and classifies crAss-like bacteriophages from human gut metagenomes, achieving their propagation and visualization.