J. Roberts

Porphyromonas gingivalis activates Heat-Shock-Protein 27 to drive a LC3C-specific pro-bacterial form of select autophagy that is redox sensitive for intracellular survival in human gingival mucosa

This paper identifies how Porphyromonas gingivalis uses HSp27 phosphorylation to drive a redox-sensitive, LC3C-specific autophagy mechanism that supports its intracellular survival in human gingival cells.

Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

A new paradigm of intracrine free fatty acid receptor 4 signaling at lipid droplets

The paper shows FFA4, a GPCR, signals from lipid droplet-associated membranes in adipocytes, providing localized feedback to regulate lipolysis.

Evolutionarily diverse origins of honey bee deformed wing viruses

This study reconstructs the origins and spread of Deformed Wing Viruses in honey bees using phylogeographic analysis, revealing distinct evolutionary paths for DWV-A and DWV-B.

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

Green leaf volatiles co-opt proteins involved in molecular pattern signaling in plant cells

The paper shows GLVs induce similar early stress responses as DAMPs by altering phosphorylation of proteins involved in signaling pathways.

Residual Complex I activity supports glutamate catabolism and mtSLP via canonical Krebs cycle activity during acute anoxia without OXPHOS

The paper shows that residual Complex I activity sustains glutamate catabolism and mtSLP during acute anoxia by oxidizing NADH with endogenous quinones, bypassing OXPHOS.

Machine Learning Optimization of Photosynthetic Microbe Cultivation and Recombinant Protein Production

This study uses machine learning to optimize culture conditions for producing therapeutic proteins in spirulina, doubling production and improving volumetric productivity by 70-100%.

Direct RNA sequencing and early evolution of SARS-CoV-2

The paper presents the first native RNA sequence of SARS-CoV-2, detailing its transcriptome and epitranscriptome, and infers genetic features and evolutionary rate.

T-ALL Proliferation Relies on Glutamine Uptake and EAAT1-dependent Conversion of Glutamine to Aspartate and Nucleotides

This study identifies EAAT1 as a critical target for T-ALL treatment by showing its role in glutamine conversion to nucleotides and aspartate essential for cell proliferation.

Different strategies to manage Varroa jacobsoni and Tropilaelaps mercedesae in Papua New Guinea

The paper evaluates the effectiveness of brood manipulation strategies and a chemical miticide for managing Varroa jacobsoni and Tropilaelaps mercedesae in Papua New Guinea.

Cell explosions: single cell death triggers an avoidance response in local populations of the ecologically prominent phytoplankton genus Micromonas

The paper shows that single cell death in Micromonas sp. triggers an avoidance response in neighboring cells, modeled as a diffusing chemical patch.

Evidence for rapid phenotypic and behavioral change in a recently established cavefish population

This study compares phenotypic and behavioral traits between a recently established cavefish population and its surface counterpart, finding significant differences in morphology and behavior.

NMR Methods for Quantitative Isotopomer Rates in Real-Time Metabolism of Cells

The paper compares 13C-filtered and 13C-edited NMR methods for quantifying isotopomer rates in real-time cell metabolism, finding a double-filter approach suitable for cancer cell studies.