Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control
F. Nadler, E. Lavdovskaia, A. Krempler, L. D. Cruz-Zaragoza, S. Dennerlein, R. Richter-Dennerlein
The paper identifies mtRF1 as the specialized release factor for COX1 translation termination in human mitochondria and shows its ablation causes COX deficiency and activates quality control mechanisms.
bioRxiv · Jul 8, 2022Biochemistry