BiochemistrybioRxiv
Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control
F. Nadler, E. Lavdovskaia, A. Krempler…·R. Richter-Dennerlein
The paper identifies mtRF1 as the specialized release factor for COX1 translation termination in human mitochondria and shows its ablation causes COX deficiency and activates quality control mechanisms.
DOI 10.1038/s41467-022-34088-w