tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10
S. E. Strassler, I. E. Bowles, A. Krishnamohan, H. Kim, C. B. Edgington, E. G. Kuiper, C. J. Hancock, L. Comstock, J. E. Jackman, G. L. Conn
This study identifies that Trm10 substrate recognition depends on tRNA conformational changes induced by the enzyme, revealing a novel mechanism for tRNA modification.
bioRxiv · Feb 1, 2023Biochemistry