G. L. Conn

30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC

This paper determines the structure of RmtC bound to the 30S ribosomal subunit and identifies key residues involved in G1405 modification, providing insights for inhibitor development.

Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition

This study optimizes berberine derivatives to create di-berberine conjugates that enhance aminoglycoside efficacy by inhibiting Pseudomonas aeruginosa MexY efflux pump function.

tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10

This study identifies that Trm10 substrate recognition depends on tRNA conformational changes induced by the enzyme, revealing a novel mechanism for tRNA modification.

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

This paper reports the structure of the Mycobacterium tuberculosis TlyA enzyme bound to the 50S ribosomal subunit, revealing mechanisms of rRNA substrate recognition and modification that contribute to antibiotic resistance.

Targeted redesign of suramin analogs for novel antimicrobial lead development

This paper develops a computational framework to design suramin analogs with specific antiviral and antibacterial activity by virtual screening against viral and bacterial protein targets.

Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition

This study identifies functionally critical residues in RmtC that distinguish between 30S-binding affinity and 16S rRNA modification through structural and biochemical analysis.

Substrate recognition by the Pseudomonas aeruginosa EF-Tu methyltransferase EftM

This study defines the molecular mechanism of EF-Tu substrate recognition by the Pseudomonas aeruginosa methyltransferase EftM through computational modeling and experimental validation.

Dysregulation of M segment gene expression contributes to influenza A virus host restriction

This study identifies dysregulation of M segment gene expression, particularly M2 overexpression, as a key factor in avian influenza A virus restriction in mammalian hosts.