ImmunologybioRxivPreprint
EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
A. Kuhlmann-Hogan, T. Cordes, Z. Xu…·S. M. Kaech
This study shows EGFR-mutant lung adenocarcinomas exploit alveolar macrophage metabolism via GM-CSF--PPARγ signaling to support tumor growth and EGFR signaling, suggesting new therapeutic strategies combining statins and PPARγ inhibition.
DOI 10.1101/2023.04.15.536974