C. Metallo

Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.

Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.

EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

This study shows EGFR-mutant lung adenocarcinomas exploit alveolar macrophage metabolism via GM-CSF--PPARγ signaling to support tumor growth and EGFR signaling, suggesting new therapeutic strategies combining statins and PPARγ inhibition.

Inter-organelle crosstalk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress

The paper investigates how acetyl-CoA homeostasis and lipogenesis are maintained under metabolic stress through inter-organelle crosstalk using isotope tracing in knockout cell lines.

Reduced methionine synthase (Mtr) expression creates a functional vitamin B12 deficiency that leads to uracil accumulation in mouse mitochondrial DNA

This study shows that reduced Mtr expression causes B12 deficiency, leading to uracil accumulation in mtDNA and impaired mitochondrial function in mice.

Daily running enhances molecular and physiological circadian rhythms in skeletal muscle

This study shows that daily running in mice changes their muscle circadian rhythms and improves exercise performance depending on the time of day.