Single-cell sequencing reveals a clonal expansion of pro-inflammatory synovial CD8 T cells expressing tissue homing receptors in psoriatic arthritis
F. Penkava, M. Del Castillo Velasco-Herrera, M. D. Young, N. Yager, A. Lledo Lara, C. Guzzo, A. Maroof, L. Mamanova, S. Cole, M. Efremova, D. Simone, C. C. Brown, A. L. Croxford, S. Teichmann, P. Bowness, , M. H. Al-Mossawi
The paper identifies clonal expansion of pro-inflammatory CD8 T cells in psoriatic arthritis joints using single-cell sequencing and links them to tissue homing receptors and antigen specificity.
bioRxiv · Jul 16, 2019Immunology