The P-selectin ligand PSGL-1 (CD162) is efficiently incorporated by primary HIV-1 isolates and can facilitate trans-infection
J. Burnie, A. T. Persaud, L. Thaya, Q. Liu, H. Miao, S. Grabinsky, V. Norouzi, P. Lusso, V. A. Tang, C. Guzzo
This paper shows that PSGL-1 is incorporated into HIV-1 virions, reducing infectivity, but also facilitates trans-infection by binding P-selectin.
bioRxiv · Jun 29, 2021Microbiology