S. Teichmann

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping

The paper creates a single-cell reference map of NK cells and identifies tumor-associated states predictive of patient outcomes in melanoma and osteosarcoma.

Multimodal decoding of human liver regeneration

This study uses single-nuclei RNA sequencing and spatial profiling to create a single-cell atlas of human liver regeneration, identifying a novel migratory hepatocyte subpopulation and demonstrating that wound closure precedes hepatocyte proliferation.

Early human lung immune cell development and its role in epithelial cell fate

The paper profiles lung immune cells during development using scRNAseq and identifies IL-1β's role in driving epithelial progenitor differentiation.

Dandelion utilizes single cell adaptive immune receptor repertoire to explore lymphocyte developmental origins

Dandelion improves V(D)J analysis in scVDJ-seq data, enabling better lineage commitment predictions and insights into lymphocyte development.

Intestinal lamina propria supports acquired eTreg suppressor function

This study identifies spatially compartmentalized Treg subsets in the gut, showing that lamina propria supports acquired eTreg suppressor function through specific interactions with IL-1β+ macrophages and ILC2.

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

Mosquito cellular immunity at single-cell resolution

The paper profiles hemocytes from two mosquito species to reveal functional diversity and identifies a new cell type, providing an atlas of mosquito immune cells at single-cell resolution.

Cellular mRNA signals in human kidney tumors

This study analyzes mRNA signals in 1,300 kidney tumors to determine their differentiation state and origin, finding that childhood tumors show fetal signals while most adult tumors do not, with exceptions in certain cancer types.

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

This study uses single-cell RNA sequencing to analyze human bone marrow HSCs and MKs, identifying MK primed HSC clusters and transcriptional changes during MK maturation and their association with myocardial infarction.

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

The paper maps pregnenolone interactomes in cancer and immune cells using chemical biology and chemoproteomics to identify proteins involved in its trafficking and non-genomic actions.

Single-cell sequencing reveals a clonal expansion of pro-inflammatory synovial CD8 T cells expressing tissue homing receptors in psoriatic arthritis

The paper identifies clonal expansion of pro-inflammatory CD8 T cells in psoriatic arthritis joints using single-cell sequencing and links them to tissue homing receptors and antigen specificity.

A novel innate lymphoid cell delineates childhood autoimmune arthritis

The paper identifies a novel synovial innate lymphoid cell (ILC) subtype associated with a specific type of childhood autoimmune arthritis, highlighting its role in inflammation and potential as a therapeutic target.