Childhood cancer mutagenesis caused by a domesticated DNA transposase
R. Keller, M. Yamada, D. Cameron, H. Suzuki, R. Sanghrajka, J. Vaynshteyn, J. Gerwin, F. Maura, W. Hooper, M. Shah, N. Robine, P. Demarest, N. S. Bayin, L. Jubierre, M. D. Taylor, , A. Kentsis
This study identifies PGBD5 as a primary mutator in medulloblastoma by showing it drives somatic DNA rearrangements in cerebellar progenitor cells.
bioRxiv · Jul 5, 2022 · PreprintCancer Biology