Tyrosyl-DNA phosphodiesterase 1 and topoisomerase I activities as predictive indicators for Glioblastoma susceptibility to genotoxic agents
W. Wang, M. Rodriguez-Silva, A. M. Acanda de la Rocha, A. L. Wolf, Y. Lai, Y. Liu, W. C. Reinhold, Y. Pommier, J. W. Chambers, Y.-C. Tse-Dinh
This study identifies the TDP1/TOP1 activity ratio as a predictive indicator for GBM susceptibility to irinotecan, suggesting TDP1 inhibition could enhance treatment efficacy.
bioRxiv · Jul 14, 2019Cancer Biology