Y. Lai

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 Hamsters

This study characterizes SARS-CoV-2 BA.5 variants in H11-K18 hACE2 golden hamsters, showing disease progression and severity similar to human infections, supporting the model's utility for research.

IOBR2: Multidimensional Decoding Tumor Microenvironment for Immuno-Oncology Research

IOBR2 is a tool for analyzing tumor microenvironment using multi-omics data, offering modules for preprocessing, estimation, interaction analysis, and visualization.

Nerve Growth Factor Receptor Limits Inflammation to Promote Remodeling and Repair of Osteoarthritic Joints

This study identifies NGFR's role in limiting inflammation to promote joint remodeling and repair in osteoarthritis by modulating NF-κB and BMP-SMAD1 signaling.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

A partial Drp1 knockout improves autophagy flux independent of mitochondrial function

This study shows that partial Drp1 knockout enhances autophagy flux without affecting mitochondrial function, revealing a distinct protective mechanism against manganese toxicity.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Screening of hydrocarbon-stapled peptides for inhibition of calcium-triggered exocytosis

The paper screens hydrocarbon-stapled peptides targeting the SNARE-Syt1 primary interface to inhibit Ca2+-triggered exocytosis and mucus hypersecretion.

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in PSC.

This study identifies protective and aggressive bacterial subsets and metabolites in PSC patients and mice, showing their impact on hepatobiliary inflammation and fibrosis.

Discovery of nanobodies against SARS-CoV-2 and an uncommon neutralizing mechanism

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

Structure of mycobacterial cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating PPARγ-UCP2 cascade

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Restoration of β-globin expression with optimally designed lentiviral vector for β-thalassemia treatment in Chinese patients

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

High-throughput CRISPR screens to dissect macrophage-Shigella interactions

This study uses CRISPR screens to identify host factors involved in Shigella-induced inflammation and macrophage survival, revealing potential therapeutic targets.

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

Illuminating host-mycobacterial interactions with functional genomic screening to inhibit mycobacterial pathogenesis

This study uses CRISPR screens to identify host genes that inhibit mycobacterial growth, revealing potential targets for host-directed tuberculosis therapies.

GmPTF1 Modifies Root Architecture Responses to Phosphate Starvation in Soybean

This study identifies GmPTF1 as a regulator of GmEXPB2 expression, modifying soybean root architecture to enhance phosphate acquisition and biomass.

Tyrosyl-DNA phosphodiesterase 1 and topoisomerase I activities as predictive indicators for Glioblastoma susceptibility to genotoxic agents

This study identifies the TDP1/TOP1 activity ratio as a predictive indicator for GBM susceptibility to irinotecan, suggesting TDP1 inhibition could enhance treatment efficacy.

Enabling Precision Medicine via standard communication of NGS provenance, analysis, and results

The paper introduces the BioCompute framework to standardize genomic data reporting, enabling reproducibility and interoperability in precision medicine.