Author

A. Lehner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Eshwar· 1 shared A. J. Fletcher· 1 shared D. B. Grabarczyk· 1 shared E. Roitinger· 1 shared J. Ahel· 1 shared J. Anes· 1 shared K. Dever· 1 shared L. Deszcz· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMicrobiology

A. Eshwar

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2 papers

Recent·Most cited

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

J. Ahel, A. J. Fletcher, D. B. Grabarczyk, E. Roitinger, L. Deszcz, A. Lehner, S. Virdee, T. Clausen

This study identifies a non-canonical zinc finger active site in RNF213 and shows its E3 activity depends on ATP binding and adenine nucleotide ratios.

bioRxiv · May 10, 2021Biochemistry

Analysis of the oxidative stress regulon identifies soxS as a genetic target for resistance reversal in multi-drug resistant Klebsiella pneumoniae

J. Anes, K. Dever, A. Eshwar, S. Nguyen, Y. Cao, S. K. Sivasankaran, S. Sakalauskaite, A. Lehner, S. Devineau, R. Daugelavicius, S. Fanning, S. Srikumar

This study identifies soxS as a genetic target for reversing multi-drug resistance in K. pneumoniae by analyzing its oxidative stress regulon and demonstrating its role in efflux pump regulation and tetracycline susceptibility.

bioRxiv · Aug 21, 2020Microbiology