Author

T. Clausen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 6 Cell Biology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Assay:proteomics· 6 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Organism:plant (other)· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

A. Meinhart· 4 shared L. Deszcz· 3 shared R. Beveridge· 3 shared A. Shulkina· 2 shared A. Vogel· 2 shared D. B. Grabarczyk· 2 shared D. Haselbach· 2 shared F. Ikeda· 2 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

A. Meinhart

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy

J. F. Ehrmann, D. B. Grabarczyk, M. Heinke, L. Deszcz, R. Kurzbauer, O. Hudecz, A. Shulkina, R. Gogova, A. Meinhart, G. A. Versteeg, T. Clausen

The paper determines the cryo-EM structure of BIRC6 and its complex with HTRA2 and SMAC, revealing how SMAC inhibits BIRC6 to regulate apoptosis and autophagy.

bioRxiv · Aug 30, 2022 · PreprintBiochemistry

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

S. Scinicariello, A. Soederholm, M. Schaefer, A. Shulkina, I. Schwartz, K. Hacker, R. Gogova, R. Kalis, K. Froussios, V. Budroni, A. Bestehorn, T. Clausen, P. Kovarik, J. Zuber, G. A. Versteeg

This study identifies HUWE1 as a regulator of TTP proteasomal degradation by controlling its phosphorylation, distinct from MAPK-mediated phosphorylation.

bioRxiv · Aug 29, 2022Cell Biology

UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome

A. Vogel, R. Arnese, R. Gudino Carrillo, D. Sehr, A. Bylicki, A. Meinhart, T. Clausen

This study identifies the FX3HY motif as essential for UNC-45-mediated myosin folding, linking its disruption to Freeman Sheldon Syndrome and myopathies.

bioRxiv · Aug 8, 2022Biochemistry

Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy

L. Picchianti, V. Sanchez de Medina Hernandez, N. Zhan, N. A. T. Irwin, M. Stephani, H. Hornegger, R. Beveridge, J. Sawa-Makarska, T. Lendl, N. Grujic, S. Martens, T. A. Richards, T. Clausen, S. Ramundo, E. G. Karagoz, Y. Dagdas

The paper shows that non-canonical shuffled ATG8 interacting motifs in C53 link UFMylation and autophagy, revealing an ancestral regulatory mechanism for ER homeostasis.

bioRxiv · Apr 26, 2022Plant Biology

BacPROTACs mediate targeted protein degradation in bacteria

F. E. Morreale, S. Kleine, J. Leodolter, S. Ovchinnikov, J. Kley, R. Kurzbauer, D. M. Hoi, A. Meinhart, M. Hartl, D. Haselbach, M. Kaiser, T. Clausen

This paper develops BacPROTACs, small-molecule degraders that target bacterial proteins by activating the ClpC:ClpP protease, demonstrating in vivo degradation in mycobacteria.

bioRxiv · Jun 9, 2021Biochemistry

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

J. Ahel, A. J. Fletcher, D. B. Grabarczyk, E. Roitinger, L. Deszcz, A. Lehner, S. Virdee, T. Clausen

This study identifies a non-canonical zinc finger active site in RNF213 and shows its E3 activity depends on ATP binding and adenine nucleotide ratios.

bioRxiv · May 10, 2021Biochemistry

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

M. Stephani, L. Picchianti, A. Gajic, R. Beveridge, E. Skarwan, V. Sanchez de Medina Hernandez, A. Mohseni, M. Clavel, Y. Zeng, C. Naumann, M. Matuszkiewicz, E. Turco, C. Loefke, B. Li, G. Durnberger, , Y. Dagdas

The paper identifies C53 as a conserved ER-phagy receptor that links autophagy with ribosome-associated quality control during ER stress in plants and mammals.

eLife · Aug 27, 2020Peer-reviewedCell Biology

The linear ubiquitin chain assembly complex generates heterotypic ubiquitin chains

A. R. Carvajal, C. G. Diaz, A. Vogel, A. Sonn-Segev, K. Schodl, L. Deszcz, Z. Orban-Nemeth, S. Sakamoto, K. Mechtler, P. Kukura, T. Clausen, D. Haselbach, F. Ikeda

This study shows LUBAC generates heterotypic ubiquitin chains with linear and oxyester-linked branches through coordinated action of HOIP and HOIL-1L.

bioRxiv · May 27, 2020Biochemistry

Native mass spectrometry can effectively predict PROTAC efficacy

R. Beveridge, D. Kessler, K. Rumpel, P. Ettmayer, A. Meinhart, T. Clausen

This study shows native mass spectrometry can detect PROTAC-mediated protein interactions and identify preferred E3-PROTAC-POI combinations in competition experiments.

bioRxiv · Nov 25, 2019Biochemistry