E. Roitinger

Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral-induced cellular damage

This study shows that metabolic enzymes act as autophagy receptors in plants to degrade defense executors during viral infection, revealing autophagy as a tolerance pathway rather than an antiviral defense.

A molecular network of conserved factors keeps ribosomes dormant in the egg

The paper identifies conserved factors that maintain ribosome dormancy in zebrafish and Xenopus eggs and embryos, transitioning to an active state during early development.

Glucose intolerance in aging is mediated by the Gpcpd1-GPC metabolic axis

This study identifies Gpcpd1-GPC metabolic pathway perturbation in aging muscle as a driver of glucose intolerance.

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

This study identifies a non-canonical zinc finger active site in RNF213 and shows its E3 activity depends on ATP binding and adenine nucleotide ratios.

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

The paper shows that ESCO1 and CTCF protect cohesinSTAG1 from WAPL, enabling long chromatin loops that persist during G1-phase.

N-terminal β-strand underpins biochemical specialization of an ATG8 isoform

The paper identifies the N-terminal β-strand and a single amino acid polymorphism as key determinants of binding specificity for the ATG8 isoform in potato, shaping interactions with PexRD54 and other plant proteins.