Author

A. J. Fletcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Lehner· 1 shared C. S. Green· 1 shared D. B. Grabarczyk· 1 shared E. Roitinger· 1 shared J. Ahel· 1 shared J. Duce· 1 shared J. Skidmore· 1 shared K. F. Winklhofer· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. Lehner

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2 papers

Recent·Most cited

Antibody-dependent Intracellular neutralisation by TRIM21 is potentiated by HOIP and linear ubiquitin chains

C. S. Green, K. F. Winklhofer, A. J. Fletcher, L. C. James, J. Skidmore, J. Duce, W. A. McEwan

This study identifies HOIP and linear ubiquitin chains as critical for TRIM21-mediated ADIN by recruiting VCP, enhancing virus neutralization.

bioRxiv · Apr 2, 2024 · PreprintImmunology

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

J. Ahel, A. J. Fletcher, D. B. Grabarczyk, E. Roitinger, L. Deszcz, A. Lehner, S. Virdee, T. Clausen

This study identifies a non-canonical zinc finger active site in RNF213 and shows its E3 activity depends on ATP binding and adenine nucleotide ratios.

bioRxiv · May 10, 2021Biochemistry