Author

A. Leonard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

N. J. Sniadecki· 2 shared A. Emery· 1 shared A. Wolf-Yadlin· 1 shared B. Gurchenkov· 1 shared C. banal· 1 shared C. E. Murry· 1 shared C. Rieu· 1 shared D.-H. Kim· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

N. J. Sniadecki

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Black Dots: Microcontact-Printed, Reference-Free Traction Force Microscopy

K. M. Beussman, M. Y. Mollica, A. Leonard, J. Miles, J. Hocter, Z. Song, M. Stolla, S. J. Han, A. Emery, W. E. Thomas, N. J. Sniadecki

This paper introduces a traction force microscopy technique called 'black dots' to measure cellular forces without constraining cell shape, finding that higher force correlates with increased spread area, circularity, and F-actin uniformity in platelets.

bioRxiv · Aug 2, 2021Bioengineering

C-STEM: ENGINEERING NICHE-LIKE MICRO-COMPARTMENTS FOR OPTIMAL AND SCALE-INDEPENDENT EXPANSION OF HUMAN PLURIPOTENT STEM CELLS IN BIOREACTORS

P. J. R. Cohen, E. Luquet, J. Pletenka, A. Leonard, E. Warter, B. Gurchenkov, J. Carrere, C. Rieu, J. Hardouin, F. Moncaubeig, M. Lanero, E. Quelennec, H. Wurtz, E. Jamet, M. Demarco, , k. Alessandri

This study develops a bioreactor system using microfluidic microcapsules to enhance hPSC expansion, achieving a 282-fold amplification in 6.5 days.

bioRxiv · Jul 5, 2021 · PreprintBioengineering

Identifiability of speciation times under the multispecies coalescent

L. Kubatko, A. Leonard, J. Chifman

This paper shows that branch lengths in fixed species trees with three or four taxa are identifiable and develops estimators and a hypothesis test for delimiting species under the coalescent model.

bioRxiv · Nov 24, 2020Evolutionary Biology

Functional Maturation of Human iPSC-based Cardiac Microphysiological Systems with Tunable Electroconductive Decellularized Extracellular Matrices

J. H. Tsui, A. Leonard, N. D. Camp, J. T. Long, Z. Y. Nawas, R. Chavanachat, J. S. Choi, A. Wolf-Yadlin, C. E. Murry, N. J. Sniadecki, D.-H. Kim

This study develops tunable electroconductive hydrogels to enhance maturation of hiPSC-derived cardiac tissues, showing improved contractile and electrophysiological function and drug response.

bioRxiv · Sep 30, 2019Bioengineering