D.-H. Kim

Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

This study shows matrix rigidity enhances M2 macrophage activation by altering nuclear mechanics and chromatin accessibility through cooperation with biochemical signals like IL4/13.

Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19

This study shows that SARS-CoV-2 infection causes persistent cardiac conduction system dysfunction in hamsters, driven by innate immune activation and mitochondrial ROS, with potential implications for long COVID.

Sex Differences and Role of Lysyl Oxidase Like 2 (LOXL2) in Angiotensin II-Induced Hypertension in Mice

This study investigates sex differences and the role of LOXL2 in Ang II-induced hypertension, finding that LOXL2 depletion protects males but worsens female aortic contractility.

Murine Parainfluenza Virus Persists in Lung Innate Immune Cells Sustaining Chronic Lung Pathology

This study shows that Sendai virus persists in lung innate immune cells, leading to chronic lung disease by upregulating antiviral and inflammatory genes.

ULK1 forms distinct oligomeric states and nanoscopic structures during autophagy initiation

This study uses single-molecule imaging to show ULK1 forms distinct clusters during autophagy initiation, with cluster size and composition correlating with autophagosome formation.

Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS

The paper uses 3D OrbiSIMS to analyze metabolite signatures in tissue around implanted medical devices, linking them to pro- or anti-inflammatory immune responses.

Survivin Regulates Intracellular Stiffness and Extracellular Matrix Production in Vascular Smooth Muscle Cells

This study shows survivin regulates intracellular stiffness and ECM production in VSMCs, linking it to arterial stiffness and vascular disease.

Perpendicular Shear Stresses Drive Transmural Helical Remodeling in Engineered Human Ventricular Models

This study shows that perpendicular shear stress drives helical transmural remodeling in engineered human ventricles, revealing how physical forces influence cardiac architecture.

Early flowering in oilseed-type Brassica rapa plants results from nonsense-mediated mRNA decay (NMD) of BrFLC2

The study identifies NMD-mediated degradation of BrFLC2 mRNA as the cause of early flowering in oilseed-type Brassica rapa LP08 plants.

Development of A Decellularized Meniscus Matrix-Based Nanofibrous Scaffold for Meniscus Tissue Engineering

This paper develops a nanofibrous scaffold using decellularized meniscus matrix and synthetic polymers to enhance meniscus cell function and matrix production.

Sequential 3D OrbiSIMS and LESA-MS/MS-based metabolomics for prediction of brain tumor relapse from sample-limited primary tissue archives

The paper uses sequential 3D OrbiSIMS and LESA-MS/MS to profile metabolites in FFPE pediatric ependymoma tissues and predict tumor relapse.

VIL1, a Polycomb-associated protein, modulates high ambient temperature response via H3K27me3 and H2A.Z in Arabidopsis thaliana

Functional Maturation of Human iPSC-based Cardiac Microphysiological Systems with Tunable Electroconductive Decellularized Extracellular Matrices

This study develops tunable electroconductive hydrogels to enhance maturation of hiPSC-derived cardiac tissues, showing improved contractile and electrophysiological function and drug response.

A NOVEL MECHANISM FOR NF-κB-ACTIVATION VIA IκB-AGGREGATION: IMPLICATIONS FOR HEPATIC MALLORY-DENK-BODY INDUCED INFLAMMATION

This study identifies a novel mechanism of NF-κB activation through IκB sequestration into insoluble aggregates along with aggregation-prone proteins in MDB-inducing models.

Clathrin-coated Pits are Shredded Organelles Presorting Receptors in the Plasma Membrane

The paper shows clathrin-coated pits pre-sort receptors on the plasma membrane to modulate their activation, with EGFR and TfR using mutually exclusive CCP subsets.