The expression of class II major histocompatibility molecules on breast tumors delays T cell exhaustion, expands the T cell repertoire and slows tumor growth
T. McCaw, M. Li, D. Starenki, S. Cooper, S. Meza-Perez, R. Arend, A. LoBuglio, D. Buchsbaum, A. Forero, T. Randall
This study shows that MHCII expression on breast tumors slows growth, recruits more T cells, expands TCR diversity, and delays exhaustion, but does not prevent exhaustion.
bioRxiv · Apr 3, 2018Immunology