Author

A. Forero

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Organism:mouse· 6 Assay:bulk RNA-seq· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. C. Eddy· 3 shared A. Kenney· 3 shared A. Zani· 3 shared J. S. Yount· 3 shared A. Karp· 2 shared C. Cai· 2 shared E. A. Hemann· 2 shared E. Hemann· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersImmunology

A. C. Eddy

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

ERK5 Signaling is Required for Type III IFN-mediated Mucosal Antiviral Responses

H. Bone, D. S. Natour, M. I. McFadden, A. Karp, A. Basu, A. Keller, P. J. Denz, P. L. Collins, M. M. Mihaylova, J. S. Yount, A. Forero

The paper identifies ERK5 as a potentiator of STAT1 activation and ISG expression, enhancing type III IFN-mediated antiviral responses in epithelial cells.

bioRxiv · May 21, 2024 · PreprintImmunology

Innate immune control of influenza virus interspecies adaptation

P. J. Denz, S. Speaks, A. D. Kenney, A. C. Eddy, J. L. Papa, J. Roettger, S. C. Scace, E. A. Hemann, A. Forero, R. J. Webby, A. S. Bowman, J. S. Yount

This study shows that IFITM3 deficiency in mice allows avian influenza viruses to infect and adapt more effectively, suggesting a role for IFITM3 in preventing zoonotic virus emergence.

bioRxiv · Aug 23, 2023 · PreprintMicrobiology

Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

S. Speaks, A. Zani, A. Solstad, A. Kenney, M. McFadden, L. Zhang, A. C. Eddy, A. O. Amer, R. Robinson, C. Cai, J. Ma, E. Hemann, A. Forero, J. Yount

This study shows that gasdermin D promotes influenza virus-induced mortality by amplifying neutrophil-driven inflammation.

bioRxiv · Mar 8, 2023Immunology

MEF2A suppresses replicative stress responses that trigger DDX41-dependent IFN production

J. R. Smith, J. W. Dowling, A. Karp, J. Schwerk, R. Savan, A. Forero

This study shows MEF2A suppresses type I IFN production by preventing R-loop accumulation and DDX41/STING pathway activation in response to replicative stress.

bioRxiv · Sep 15, 2022Immunology

Pleural macrophages translocate to the lung during infection to promote improved influenza outcomes

J. P. Stumpff, S. Y. Kim, A. Forero, A. Nishida, Y. Steuerman, I. Gat-Viks, M. G. Nair, J. Morrison

This study identifies pleural macrophages migrating to the lung during influenza infection, which correlates with improved disease outcomes.

bioRxiv · May 25, 2022Microbiology

Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice

A. Zani, A. Kenney, J. Kawahara, A. C. Eddy, X.-L. Wang, M. KC, M. Lu, E. A. Hemann, J. Li, M. E. Peeples, L. Hall-Stoodley, A. Forero, C. Cai, J. Ma, J. S. Yount

This study shows that IFITM3 protects mice from severe SARS-CoV-2 infection by limiting viral spread and inflammation, as demonstrated through knockout mouse models.

bioRxiv · Dec 22, 2021 · PreprintImmunology

Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis

M. Eltobgy, A. Zani, A. Kenney, S. Estfanous, E. Kim, A. Badr, C. Carafice, K. Daily, O. Whitham, M. Pietrzak, A. Webb, J. Kawahara, A. Eddy, P. Denz, M. Lu, , A. Amer

This study shows that caspase-4/11 worsens SARS-CoV-2 infection by increasing inflammation and thrombosis, independent of GSDMD, suggesting it as a potential drug target for severe COVID-19.

bioRxiv · Sep 24, 2021Immunology

Endomembrane targeting of human OAS1 p46 augments antiviral activity

F. W. Soveg, J. Schwerk, N. S. Gokhale, K. Cerosaletti, J. R. Smith, E. Pairo-Castineira, A. M. Kell, A. Forero, S. A. Zaver, K. Esser-Nobis, J. Roby, T.-Y. Hsiang, S. Ozarkar, J. M. Clingan, E. T. McAnarney, , R. Savan

This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.

bioRxiv · Apr 21, 2021Immunology

The expression of class II major histocompatibility molecules on breast tumors delays T cell exhaustion, expands the T cell repertoire and slows tumor growth

T. McCaw, M. Li, D. Starenki, S. Cooper, S. Meza-Perez, R. Arend, A. LoBuglio, D. Buchsbaum, A. Forero, T. Randall

This study shows that MHCII expression on breast tumors slows growth, recruits more T cells, expands TCR diversity, and delays exhaustion, but does not prevent exhaustion.

bioRxiv · Apr 3, 2018Immunology