M. Li

Mouse Cardiac Regeneration Database (MCAREDB): a single-cell atlas of neonatal cardiac regeneration in mice

MCAREDB integrates scRNA-seq datasets from mouse cardiac regeneration studies to enable comparative analysis of gene expression and pathways across developmental and injury contexts.

Transcription factor binding site divergence across maize inbred lines drives transcriptional and phenotypic variation

The paper identifies TF binding site divergence between maize inbred lines and links it to gene expression and phenotypic variation.

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

This study shows that IDH1 deficiency causes chromatin state reprogramming in human erythropoiesis by altering H3K79me3 distribution and upregulating SIRT1, leading to impaired erythropoiesis.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

The impact of model misspecification on phylogenetic network inference

This study evaluates how model misspecification affects phylogenetic network inference using simulated and biological data, finding that gene tree estimation error and substitution rate heterogeneity impact accuracy.

Detection and decontamination of chronic wasting disease prions during venison processing

This study demonstrates that CWD prions can contaminate processing surfaces and be transferred to CWD-negative venison, but can be inactivated using bleach and potassium peroxymonosulfate.

Contrast-enhanced photon-counting micro-CT of tumor xenograft models

This study evaluates contrast agents for photon-counting micro-CT in tumor xenografts, finding that Exitrone Nano 12000 provides better vasculature enhancement and consistency compared to ISOVUE-370.

Establishing a Male-Positive Genetic Sexing Strain in the Asian Malaria Vector Anopheles stephensi

This paper applies the SEPARATOR system to Anopheles stephensi to enable male-specific genetic sexing for biocontrol, confirming evolutionary conservation of sex-specific splicing.

Moderate Cold Stress Enhance Drought Resistance through CCA1 via -an ABA- independent Pathway

This study shows that moderate cold stress improves Arabidopsis drought tolerance through the CCA1 pathway, independent of ABA, by promoting stomatal closure and proline accumulation before drought occurs.

Deterministic processes played more important roles than stochastic processes in driving community assembly of ectomycorrhizal fungal associated with Pinus tabuliformis - an endemic Pinaceae species in China

The study examines EM fungal communities associated with Pinus tabuliformis, finding deterministic processes dominate community assembly over stochastic processes.

A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

The paper identifies a Pseudomonas aeruginosa VgrG2b fragment cleaved by caspase-11 that inhibits NLRP3 inflammasome activation, promoting infection and improving survival with a specific peptide inhibitor.

Activation of NLRP3 inflammasome/pyroptosis by protease inhibitor atazanavir at high concentrations is mediated through mitochondrial dysfunction

This study shows high concentrations of atazanavir induce mitochondrial dysfunction and NLRP3 inflammasome/pyroptosis in T cells, leading to apoptosis.

Genomic characterization of Escherichia coli harbor a polyketide synthase (pks) island associated with colorectal cancer (CRC) development

This study characterizes the genomic distribution and evolution of pks islands in E. coli strains associated with colorectal cancer, revealing phylogenetic patterns and horizontal gene transfer.

Unveiling the PHR-centered regulatory network orchestrating the phosphate starvation signaling in Chinese fir (Cunninghamia lanceolata)

This study identifies ClPHRs as key regulators of phosphate starvation signaling in Chinese fir, revealing evolutionary differences in the SPX-PHR module compared to model plants.

An organoid platform reveals MEK-PARP co-targeting to enhance radiation response in rectal cancer

The paper uses a patient-derived rectal cancer organoid platform to identify MEK and PARP inhibitors that synergize with radiation to enhance treatment response in locally advanced rectal cancer.

Rapid evolution of fine-scale recombination during domestication: a perspective from population genomics

The paper constructs a fine-scale recombination map in domestic chickens to study rapid evolutionary changes in recombination rates during domestication.

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

The 11β-hydroxysteroid dehydrogenase type 1 inhibitor SPI-62 prevents morbidity in a mouse model of Cushing's syndrome

SPI-62, an HSD-1 inhibitor, reduces GC-induced morbidity in a mouse Cushing's syndrome model by improving insulin sensitivity, reducing adiposity, and preventing skeletal myopathy.

The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish

The study shows that the intestinal microbiome, specifically Cetobacterium somerae, inhibits viral infection in zebrafish via a TLR2-type I IFN signaling pathway.

Inactivation of PRMT1 inhibits cardiac fibrosis via transcriptional regulation and perturbation of FBL activity in fibroblast-to-myofibroblast transition

This study shows that inhibiting PRMT1 reduces cardiac fibrosis by blocking fibroblast-to-myofibroblast transition through transcriptional regulation and disruption of FBL activity.

TRPV4-Expressing Tissue-Resident Macrophages Regulate the Function of Collecting Lymphatic Vessels via Thromboxane A2 Receptors in Lymphatic Muscle Cells

This study identifies TRPV4-expressing macrophages as regulators of lymphatic vessel function through TXA2 receptors, suggesting therapeutic targets for lymphedema.

CPT2 mediated fatty acid oxidation is dispensable for humoral immunity

This study shows that CPT2-mediated fatty acid oxidation is not essential for humoral immunity in mice, as CPT2 deficiency does not impair B cell development, activation, or antibody production.

Human Organoid Tumor Transplantation Identifies Functional Glioblastoma - Microenvironmental Communication Mediated by PTPRZ1

The paper uses a human organoid tumor transplantation system to study glioblastoma-microenvironment interactions, identifying PTPRZ1 as a key mediator of intercellular communication.

High Refractive Index Imaging Buffer for Dual Color 3D SMLM Imaging of Thick Samples

This paper develops a high refractive index imaging buffer to improve 3D SMLM imaging depth in thick samples by reducing RI mismatch and enhancing image quality.

Exploring differences between depression and bipolar disorder through the urinary proteome

This study identifies differential proteins in urine proteomics to distinguish depression from bipolar disorder, suggesting immune-related mechanisms and potential biomarkers for diagnosis and treatment.

Jumbo phages possess independent synthesis and utilization systems of NAD+

This study identifies NAD-jumbo phages, which synthesize and utilize NAD+ for their life cycle, and finds they are widespread in various ecosystems.

Reassessing global historical R0 estimates of canine rabies

The paper reassesses global historical R0 estimates of canine rabies using improved statistical methods and finds higher R0 values with wider confidence intervals than previously reported.

Caspase-8-mediated CYLD cleavage boots LPS-induced endotoxic shock.

This study identifies Caspase-8-mediated CYLD cleavage as a mechanism promoting LPS-induced endotoxic shock and reveals CP25 as a potential biomarker.

A peptide targeting outer membrane protein A of Acinetobacter baumannii exhibits antibacterial activity by reducing bacterial pathogenicity

This paper identifies a peptide, P92, that targets AbOmpA of A. baumannii, reducing bacterial pathogenicity without inhibiting growth, showing efficacy in multiple infection models.

Whole-genome resequencing revealed the Origin and Domestication of Chinese Domestic Rabbits

This study uses whole-genome resequencing to trace the origin and domestication of Chinese domestic rabbits, identifying genetic adaptations and multiple potential origins.