Ligand-Dependent Mechanisms of C-C Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics
S. Gu, S. Maurya, A. Lona, L. Borrega-Roman, C. Salanga, D. J. Gonzalez, I. Kufareva, T. Handel
This study uses APEX2 proximity labeling and mass spectrometry to uncover ligand-dependent CCR5 trafficking mechanisms, revealing distinct internalization and degradation pathways.
bioRxiv · Nov 1, 2023 · PreprintCell Biology