Author

T. Handel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. A. Kossiakoff· 1 shared A. Lona· 1 shared C. Salanga· 1 shared C. T. Schafer· 1 shared D. J. Gonzalez· 1 shared I. Kufareva· 1 shared J. J. G. Tesmer· 1 shared L. Borrega-Roman· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. A. Kossiakoff

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Ligand-Dependent Mechanisms of C-C Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics

S. Gu, S. Maurya, A. Lona, L. Borrega-Roman, C. Salanga, D. J. Gonzalez, I. Kufareva, T. Handel

This study uses APEX2 proximity labeling and mass spectrometry to uncover ligand-dependent CCR5 trafficking mechanisms, revealing distinct internalization and degradation pathways.

bioRxiv · Nov 1, 2023 · PreprintCell Biology

ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding

Q. Chen, C. T. Schafer, S. Mukherjee, M. Gustavsson, P. Agrawal, X.-Q. Yao, A. A. Kossiakoff, T. Handel, J. J. G. Tesmer

This paper reports cryo-EM structures of ACKR3-arrestin2/3 complexes phosphorylated by GRK2 or GRK5, revealing how phosphorylation barcodes influence arrestin binding modes and receptor configuration.

bioRxiv · Jul 18, 2023 · PreprintBiochemistry