Mutagenic-end joining results in smaller deletions in heterochromatin relative to euchromatin
J. M. Miller, S. Prange, H. Ji, A. R. Rau, V. Y. Khodaverdian, X. Li, A. Patel, N. L. Butova, A. Lutter, H. Chung, C. Merigliano, C. C. Rawal, T. Hanscom, M. McVey, I. Chiolo
The paper investigates repair mechanisms in Drosophila heterochromatin and euchromatin, finding that heterochromatin favors HR over mutagenic EJ, leading to smaller deletions via SD-MMEJ.
bioRxiv · Mar 3, 2023 · PreprintCell Biology