Author

I. Chiolo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 3 Organism:Drosophila· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Merigliano· 3 shared C. P. Caridi· 2 shared L. Delabaere· 2 shared X. Li· 2 shared A. Lutter· 1 shared A. Patel· 1 shared A. R. Rau· 1 shared A. Sanchi· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

C. Merigliano

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

'Off-pore' nucleoporins relocalize heterochromatic breaks through phase separation

C. Merigliano, T. Ryu, C. D. See, C. P. Caridi, X. Li, N. Butova, T. Reynolds, C. Deng, D. M. Chenoweth, M. Capelson, I. Chiolo

The paper shows that Nup98 nucleoporins use phase separation to mobilize heterochromatic repair sites and exclude Rad51, promoting homologous recombination and genome integrity.

bioRxiv · Dec 7, 2023 · PreprintCell Biology

Replication fork plasticity upon replication stress requires rapid nuclear actin polymerization

M. D. Palumbieri, C. Merigliano, D. Gonzalez-Acosta, T. von Kaenel, B. Welter, H. Stoy, J. Krietsch, S. Ulferts, A. Sanchi, R. Grosse, I. Chiolo, M. Lopes

This study shows that nuclear actin polymerization enables replication fork plasticity by facilitating fork slowing and reversal during replication stress.

bioRxiv · Mar 24, 2023 · PreprintCancer Biology

Mutagenic-end joining results in smaller deletions in heterochromatin relative to euchromatin

J. M. Miller, S. Prange, H. Ji, A. R. Rau, V. Y. Khodaverdian, X. Li, A. Patel, N. L. Butova, A. Lutter, H. Chung, C. Merigliano, C. C. Rawal, T. Hanscom, M. McVey, I. Chiolo

The paper investigates repair mechanisms in Drosophila heterochromatin and euchromatin, finding that heterochromatin favors HR over mutagenic EJ, leading to smaller deletions via SD-MMEJ.

bioRxiv · Mar 3, 2023 · PreprintCell Biology

Arp2/3 and Unc45 maintain heterochromatin stability in Drosophila polytene chromosomes.

G. Dialynas, L. Delabaere, I. Chiolo

This paper shows that Arp2/3 and Unc45 are required for heterochromatin stability in Drosophila polytene chromosomes by enabling relocalization of DSBs.

bioRxiv · Jun 21, 2019Cell Biology

Quantitative methods to investigate the 4D dynamics of heterochromatic repair sites in Drosophila cells

C. P. Caridi, L. Delabaere, H. Tjong, H. Hopp, D. Das, F. Alber, I. Chiolo

The paper describes optimized live imaging and analysis methods to study 4D dynamics of heterochromatic repair sites in Drosophila cells, revealing biophysical properties of motion and directed movement patterns.

bioRxiv · Nov 6, 2017Cell Biology