Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling
K. B. Sugg, J. F. Markworth, N. P. Disser, A. M. Rizzi, J. R. Talarek, D. C. Sarver, S. V. Brooks, C. L. Mendias
This study shows PDGFR signaling is essential for postnatal tendon growth and remodeling, with MT1-MMP mediating fibroblast migration and being regulated by PI3K/Akt and ERK1/2.
bioRxiv · Oct 25, 2017Physiology