The memory of pathogenic IgE is contained within CD23+IgG1+ memory B cells poised to switch to IgE in food allergy
M. Ota, K. Hoehn, T. Ota, C. Aranda, S. Friedman, W. Braga, A. Malbari, S. Kleinstein, S. Sicherer, M. Curotto de Lafaille
The paper identifies CD23+IgG1+ memory B cells in peanut allergy that can switch to IgE and contain high affinity allergen-specific clones.
bioRxiv · Jan 25, 2023 · PreprintImmunology