S. Kleinstein

Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites

This study identifies antibody gene features linked to binding and functional activity in vaccine-derived human mAbs against malaria parasites, showing adjuvant effects on clonotype diversity.

The memory of pathogenic IgE is contained within CD23+IgG1+ memory B cells poised to switch to IgE in food allergy

The paper identifies CD23+IgG1+ memory B cells in peanut allergy that can switch to IgE and contain high affinity allergen-specific clones.

Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

The paper integrates transcriptional data from 13 vaccines to identify a time-adjusted signature predicting antibody responses across different vaccines.

Proteomics on longitudinal serum samples differentiates localized and disseminated Lyme disease

This study uses serum proteomics to identify biomarkers distinguishing localized and disseminated Lyme disease stages.

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

Alignment free identification of clones in B cell receptor repertoires

The paper introduces an alignment-free method to identify clones in B cell receptor repertoires, improving sensitivity without sacrificing specificity compared to junction-based distance methods.

Single-cell repertoire tracing identifies rituximab refractory B cells during myasthenia gravis relapses

The paper identifies persistent autoantibody-producing B cell clones in rituximab-treated myasthenia gravis patients during relapses, showing incomplete B cell depletion.

Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data

This paper improves B cell clonal family identification by incorporating somatic hypermutations in V and J segments with junction sequence analysis using spectral clustering.

Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults

This study identifies shared and seasonal molecular signatures of influenza vaccination in young and older adults, revealing age-specific gene expression patterns linked to antibody responses.