Metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization
S. Guetter, C. Koenig, H. Koerkel-Qu, A. Markiewicz, S. Scheitler, M. Katzer, M. Berneburg, P. Renner, B. Cucuruz, L. Guttenberger, V. Naimer, K. Weidele, S. Treitschke, C. Werno, H. Jaser, , M. Werner-Klein
This study identifies MCSP+ melanoma cells as early metastasis founder cells in lymph nodes and shows they activate immunosuppression to evade CD8 T cell attack.
bioRxiv · May 8, 2024Cancer Biology