F. Weber

Metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization

This study identifies MCSP+ melanoma cells as early metastasis founder cells in lymph nodes and shows they activate immunosuppression to evade CD8 T cell attack.

VISION -- an open-source software for automated multi-dimensional image analysis of cellular biophysics

VISION is an open-source software for automated multi-dimensional image analysis of cellular biophysics, enabling high throughput and correlative analysis of biophysical properties.

Preserved particulate organic carbon is likely derived from the subsurface sulfidic photic zone of the Proterozoic Ocean: evidence from a modern, oxygen-deficient lake

The paper links carbon isotope patterns in modern oxygen-deficient lake sediments to specific carbon fixation pathways and microbial communities, suggesting similar processes may explain Proterozoic ocean carbon signatures.

Identification of host factor for Rift valley fever Phlebovirus

This study identifies WDR7 as an essential host factor for Rift Valley fever phlebovirus and La Crosse encephalitis virus replication through CRISPR-Cas9 and siRNA screens.

Identification and in vitro characterization of UDP-GlcNAc-RNA cap-modifying and decapping enzymes

The paper identifies and characterizes enzymes that modify and decap UDP-GlcNAc-capped RNA in vitro, using synthetic capped dinucleotides for functional studies.

The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes

The paper identifies thyroglobulin gene (Tg) as a permanently upregulated gene in thyrocytes across vertebrates, providing insights into mechanisms of sustained transcriptional activation.

Functional comparisons of the virus sensor RIG-I from humans, the microbat Myotis daubentonii, and the megabat Rousettus aegyptiacus, and their response to SARS-CoV-2 infection

This study functionally compares RIG-I from microbats, megabats, and humans, showing similar antiviral function and SARS-CoV-2 sensing ability in humans and megabats but not microbats.

Single particle profiler for measuring content and properties of nano-sized bioparticles

The paper introduces a high-throughput method called single particle profiler (SPP) to analyze content and biophysical properties of nanoscale bioparticles, demonstrating its application on mRNA encapsulation, viral binding, and biophysical heterogeneity.

Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells.

The paper integrates single-cell chromatin accessibility and RNA-seq to analyze enhancer landscapes in human tumor-infiltrating T cells, identifying key regulatory elements and their role in TIL dysfunction.

Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) as an auxiliary host factor for RNA viruses including SARS-CoV-2

This study identifies LRP1 as a host factor that supports infection by multiple RNA viruses, including SARS-CoV-2, through cholesterol-dependent endocytosis.

Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response

This study shows that the Omicron variant of SARS-CoV-2 is more resistant to type I interferon responses compared to Delta and wildtype strains.

Particle-associated and free-living microbial assemblages are distinct in a permanently redox-stratified freshwater lake

The paper examines microbial assemblages in a redox-stratified lake, finding distinct particle-associated and free-living communities that respond to seasonal changes and redox conditions.

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo Hemorrhagic Fever Viruses for novel therapeutic target

This study uses multi-omics approaches to analyze host-viral interactions in CCHFV infection, identifying metabolic reprogramming and interferon-mediated antiviral mechanisms as potential therapeutic targets.

Functionalized bead assay to measure 3-dimensional traction forces during T-cell activation

This paper develops a traction force microscopy platform to quantify local 3D traction forces exerted by T-cell microvilli during activation, linking force measurements to T-cell signaling.

Lipoprotein particles interact with membranes and transfer their cargo without receptors

This study shows lipoprotein particles transfer cargo to membranes without receptors, using cryo-EM and spectroscopy, revealing receptor-independent mechanisms.

Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies

The paper identifies 200 approved drugs that target SARS-CoV-2-induced pathways, with 40 in clinical trials, and classifies them into viral replication and immune response mechanisms.

Two C++ Libraries for Counting Trees on a Phylogenetic Terrace

The paper introduces two C++ libraries that efficiently count and enumerate trees on a phylogenetic terrace using the SUPERB algorithm, outperforming a Python implementation.