C. Koenig

Compromising tyrosine hydroxylase function establishes a delusion-like temporal profile of reinforcement by dopamine neurons in Drosophila

This study shows that impairing tyrosine hydroxylase in Drosophila alters dopamine neuron reinforcement timing, mimicking delusional causality attribution in different conditioning paradigms.

Metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization

This study identifies MCSP+ melanoma cells as early metastasis founder cells in lymph nodes and shows they activate immunosuppression to evade CD8 T cell attack.

Automated high-throughput biological sex identification from archaeological human dental enamel using targeted proteomics

This paper introduces a high-throughput proteomics method for biological sex identification from archaeological human dental enamel, achieving high accuracy and scalability.

Structure of the endosomal CORVET tethering complex

The paper solves the structure of the CORVET tethering complex using cryo-EM and explains its role in promoting endosome fusion through interactions with Rab5 and PI3P.

Cofilin-Driven Nuclear Deformation Drives Dendritic Cell Migration through the Extracellular Matrix

This study shows that cofilin-1 phosphorylation drives nuclear deformation and enhances dendritic cell migration through extracellular matrix.

Enamel proteins reveal biological sex and genetic variability within southern African Paranthropus

This study uses enamel proteomics to determine biological sex and assess intraspecific variation in Paranthropus robustus from South Africa, supporting the idea that morphological variation may reflect taxonomic diversity.

Structure of the lysosomal membrane fusion machinery

This study determines the structure of HOPS, a lysosomal fusion machinery, revealing its rigid architecture and how it couples membrane tethering with SNARE assembly to facilitate fusion.

Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

The Human Exonuclease-1 Interactome And Phosphorylation Sites

This study identifies EXO1 interacting proteins and phosphorylation sites, revealing roles in DNA repair and potential cancer targets.

Disharmony of the world’s island floras

The paper quantitatively assesses island disharmony by analyzing 320 island floras and 450 plant families, finding compositional bias linked to island characteristics rather than family traits.

GIFT - A Global Inventory of Floras and Traits for macroecology and biogeography

The paper introduces GIFT, a global database integrating plant species distributions, traits, and phylogenetic data, enabling macroecological and biogeographical research.

Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and cell death

This study identifies CDC25 inhibitors that induce cell cycle arrest and cell death through a mixed-type mechanism, validated in 2D cultures and 3D organoids.