Experimental Test of Evolutionary Safety of a CRISPR-Cas9 Gene-Drive Element
M. S. Overton, S. E. Guy, X. Chen, A. Martsul, K. Carolino, O. Akbari, J. R. Meyer, S. Kryazhimskiy
The paper tests the evolutionary safety of CRISPR-Cas9 gene drives in yeast by measuring their impact on mutation rates and loss-of-heterozygosity, finding minimal effects.
bioRxiv · Nov 28, 2023 · PreprintEvolutionary Biology