Evolutionary BiologybioRxivPreprint
Experimental Test of Evolutionary Safety of a CRISPR-Cas9 Gene-Drive Element
M. S. Overton, S. E. Guy, X. Chen…·S. Kryazhimskiy
The paper tests the evolutionary safety of CRISPR-Cas9 gene drives in yeast by measuring their impact on mutation rates and loss-of-heterozygosity, finding minimal effects.
DOI 10.1101/2023.11.28.569142