X. Chen

Convergent DNA Methylation Abnormalities at Bivalent Chromatin in Human Growth Disorders

This study identifies locus-specific DNA methylation defects at bivalent chromatin as a common feature in growth disorders caused by DNMT3A or NSD1 mutations.

Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for development and pathogenicity of Fusarium graminearum

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder

The evolution of autonomy from two cooperative specialists in fluctuating environments

This study shows that autonomous genotypes can evolve from cooperative microbial specialists in fluctuating environments through horizontal gene transfer.

MtrAB two-component system is crucial for the intrinsic resistance and virulence of Mycobacterium abscessus

This study shows that disrupting MtrA or MtrB in Mycobacterium abscessus increases antibiotic susceptibility and reduces virulence by affecting cell division and permeability.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress

The paper shows that MAPK Pmk1 in fission yeast inhibits APC/C activation by phosphorylating and degrading Slp1Cdc20 under stress, revealing a conserved regulatory mechanism.

Compartmentalized localization of perinuclear proteins within germ granules in C. elegans

The paper identifies subcompartments within C. elegans germ granules and maps perinuclear proteins to specific regions, revealing a novel D granule and the role of MIP-1/EDDG-1 in germ granule architecture.

Sediment-associated processes account for most of the spatial variation in stream ecosystem respiration in the Yakima River basin

The paper evaluates a process-based model for predicting stream ecosystem respiration (ERtot) in the Yakima River basin and finds it fails to explain spatial variation, highlighting the importance of sediment-associated respiration and other factors.

A Comparative Study on the Superiority of AOS DP3-7 Over 5-ALA in Facilitating Pigment Change in Peppers

This study compares AOS DP3-7 and 5-ALA effects on pepper ripening, showing both accelerate ripening with differences in seed density and skin thickness.

Seaweed Amino Acid and L-Amino Acid Improve Coriander Growth

This study shows that seaweed amino acid (SG) and L-amino acid (LG) treatments enhance coriander growth and root development compared to a control group.

Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

Non-invasive laser speckle imaging of extra-embryonic blood vessels in intact few-days-old avian eggs

The paper demonstrates non-invasive laser speckle imaging for visualizing blood vessels in avian eggs and monitoring embryonic development with machine learning.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

High immigration rates critical for establishing emigration-driven diversity in microbial communities

The paper investigates how microbial dispersal affects community diversity under competition, finding that high immigration rates enhance diversity through emigration.

LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3

This study shows that the LRRK2 G2019S mutation impairs Th9 and Treg cell differentiation while enhancing Th2 differentiation through JAK/STAT3 signaling in T cells.

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

Chlorpromazine inhibits EAG1 channels by altering the coupling between the PAS, CNBH and pore domains

This study shows chlorpromazine inhibits EAG1 channels by disrupting PAS-CNBH domain coupling, without affecting VSD movement.

Canonical AREs are tumor suppressive regulatory elements in the prostate

This study identifies canonical AREs as tumor suppressive regulatory elements in prostate cancer, showing their reactivation can induce death in AR+ cancer cells and is linked to better prognosis.

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

This paper shows that arginine di-methylation of RIPK3 by PRMT5 prevents necroptosis in intestinal epithelial cells, maintaining homeostasis and preventing disease.

LXA4 promotes the browning of white adipose through miR-133a-3p/SIRT1 pathway

This study shows LXA4 promotes white adipose browning and improves insulin resistance via the miR-133a-3p/SIRT1 pathway in mice.

Fourfold increase in photocurrent generation of Synechocystis sp. PCC 6803 by exopolysaccharide deprivation

This study shows that reducing exopolysaccharide production in Synechocystis sp. PCC 6803 increases photocurrent by fourfold, suggesting indirect extracellular electron transfer via a diffusible mediator.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

Conserved Pseudouridines in Helix 69 of the Ribosome are Important for Ribosome Dynamics in Translation

This study shows that conserved pseudouridines in ribosome helix 69 affect ribosome dynamics and translation efficiency, particularly for rare codons.

PHOSPHATE-INDUCED 1 and its paralogs positively regulate cellulose biosynthesis in Arabidopsis.

This study shows that PHOSPHATE-INDUCED 1 and its paralogs regulate cellulose biosynthesis in Arabidopsis by modulating CSC activity in response to developmental and environmental cues.

A dual-gene reporter-amplifier architecture for enhancing the sensitivity of molecular MRI by water exchange

This paper develops a dual-gene reporter-amplifier system to enhance MRI sensitivity by using Aqp1 to facilitate water exchange, enabling detection of low-abundance Oatp1b3-expressing cells.

Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.