S. Kryazhimskiy

The paper shows that in a yeast-alga mutualism, adaptive mutations in yeast tend to enhance mutualism strength when the alga is present, despite no direct selection for cooperation.

The paper shows resistance mutations in E. coli have diverse collateral effects and proposes a method to predict and robustly rank drug pairs to minimize collateral resistance risk.

This study shows that natural selection can stall in improving a cellular module, the translation machinery, due to epistasis and depletion of beneficial mutations in E. coli.

The paper evolves yeast populations in different environments and finds that pleiotropic effects of mutations are shaped by both deterministic factors and stochastic mutation accumulation.

The paper shows that more-fit yeast genotypes are less robust to deleterious mutations, as they exhibit lower mean and higher variance in mutation fitness effects.

The paper quantifies genetic variation in adaptability and pleiotropy in budding yeast offspring, finding that initial genotype affects adaptability and pleiotropy, with heritable differences arising from natural variation.