Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer
L. G. Cornell, S. Peri, D. Restifo, A. Klochkova, T. R. Hartman, A. M. O'Reilly, R. Francescone, J. Franco-Barraza, N. Shah, E. Nicolas, E. A. Handorf, K. Q. Cai, A. Mazitova, I. Sloma, R. Chiaverelli, , I. Astsaturov
The paper shows that cholesterol deprivation activates TGFβ signaling, promoting basal differentiation in pancreatic cancer by stabilizing the TGFβ receptor.
bioRxiv · May 11, 2019 · PreprintCancer Biology