N. Shah

Extracellular Matrix-Induced Genes May Reduce Response to Rapamycin in LAM

This study identifies extracellular matrix genes that reduce rapamycin response in LAM cells and suggests repurposed inhibitors as potential therapies.

Comparative transcriptome reprogramming in oak galls containing asexual or sexual generations of gall wasps

This study compares transcriptome reprogramming in oak galls induced by asexual and sexual generations of two gall wasp species, finding greater similarity between sexual generations of different species than between asexual and sexual generations of the same species.

Reactive Oxygen Species Generation by Reverse Electron Transfer at Mitochondrial Complex I Under Simulated Early Reperfusion Conditions.

The paper investigates ROS generation during reperfusion, finding that Cx-I RET contributes less than previously thought, with other sources contributing significantly.

Golgi localized Arl15 regulates cargo transport, cell adhesion and motility

This study identifies Arl15's role in regulating cargo transport, cell adhesion, and motility by localizing it to the Golgi and cell surface, and shows its impact on filopodia and focal adhesion.

Lung Tumor Microphysiological System with 3D Endothelium to Evaluate Modulators of T-Cell Infiltration

This paper introduces a 3D lung tumor on chip model with endothelium to evaluate T-cell infiltration modulators and demonstrates its utility in assessing immune chemotaxis and vascular responses.

Short tandem repeats bind transcription factors to tune eukaryotic gene expression

This study shows STRs modulate TF-DNA interactions by altering binding affinities and on rates, impacting gene expression through increased TF density near target sites.

Activation of targetable inflammatory immune signaling is seen in Myelodysplastic Syndromes with SF3B1 mutations

This study identifies a longer, oncogenic IRAK4 isoform caused by SF3B1 mutations in MDS/AML, which is targetable by IRAK4 inhibition.

Quantitative evaluation of warming and hemodilution as two techniques to increase the flow rate of blood during simulated massive transfusion of packed red blood cells

This study quantifies how warming and hemodilution increase blood flow rate during simulated massive transfusion, finding warming and dilution together boost flow by 366%.

Immune-responsive biodegradable scaffolds for enhancing neutrophil regeneration

This study develops a biodegradable HA cryogel scaffold that degrades in response to neutrophils, enhancing neutrophil recovery post-HSCT and accelerating cryogel degradation.

Regional and clonal T cell dynamics at single cell resolution in immune checkpoint blockade

This study uses scTCR/RNA-seq to analyze T cell dynamics in lung cancer patients before and after ICB, finding regional heterogeneity and clonal persistence associated with clinical responses.

Mesenchymal-like glioma cells are enriched in the gelatin methacrylate hydrogels

The paper shows that glioma cells cultured in GelMA hydrogels develop a mesenchymal-like phenotype and recruit macrophages, differing from neurosphere cultures.

Automatic Identification and Avoidance of Axon Bundle Activation for Epiretinal Prosthesis

The paper develops an algorithm to detect axon bundle activation thresholds in retinal prostheses using electrical recordings, validated in macaque retina experiments.

Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance

This study defines the myeloma cell surface proteome, identifies therapeutic targets and resistance biomarkers, and presents a miniaturized surface proteomics protocol.

Immuno-Phenotyping of High-Grade Glioma Infiltrating Immune Cells Reveals Grade Specific Differences in Cells of Myeloid Origin

The paper compares immune cell phenotypes in high-grade gliomas (grade III and IV) and finds differences in myeloid cell proportions and markers between tumor types and blood.

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblastdriven nutritional support and immunosuppression

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.

CRISPR-based screens uncover determinants of immunotherapy response in Multiple Myeloma

This study uses CRISPR screens to identify mechanisms increasing BCMA expression and enhancing anti-myeloma efficacy of BCMA-targeted therapies in multiple myeloma.

Quality control of HLA-DR molecules by the lysosomal aspartyl protease, cathepsin D

This study identifies cathepsin D as a protease responsible for degrading HLA-DR molecules that lack bound peptide, regulating their lysosomal disposal and lifespan.

CDKN2C homozygous loss identifies a distinct subtype of TP53/RB1-wildtype leiomyosarcoma with frequent CIC genomic alterations and 1p/19q-codeletion

Investigation of the quorum-sensing regulon of the biocontrol bacterium Pseudomonas chlororaphis strain PA23

This study uses RNA sequencing to identify genes regulated by quorum sensing in Pseudomonas chlororaphis PA23, revealing 13% of the genome is under QS control.

Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer

The paper shows that cholesterol deprivation activates TGFβ signaling, promoting basal differentiation in pancreatic cancer by stabilizing the TGFβ receptor.

Antibiotic killing of diversely generated populations of non-replicating bacteria

This study investigates antibiotic killing of three types of non-replicating bacterial populations and finds they are consistently killed by aminoglycosides and peptide antibiotics.

Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma

The paper shows proteasome inhibitors modulate splicing in multiple myeloma, revealing spliceosome inhibition as a therapeutic target.

Extreme genetic signatures of local adaptation during plant colonization

The paper investigates genetic adaptations during the colonization of Japan by Lotus japonicus, identifying genomic regions and candidate genes associated with overwintering and flowering time traits.

Dual BRD4 and AURKA Inhibition is Synergistic against MYCN-amplified and nonamplified Neuroblastoma

This paper shows that combining BRD4 and AURKA inhibitors synergistically inhibits neuroblastoma cell viability and prolongs survival in xenograft models.

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

This study identifies 535 novel genetic loci associated with blood pressure traits in over one million individuals of European ancestry.