Author

E. Nicolas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Evolutionary Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Research Focus:chromatin & epigenetic regulation· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

J. Virgo· 3 shared K. Q. Cai· 3 shared K. Van Doninck· 3 shared Y. Zhou· 3 shared A. Derzelle· 2 shared A. Houtain· 2 shared A. Klochkova· 2 shared B. Hallet· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

J. Virgo

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Transgenerational chromosome repair in the asexual bdelloid rotifer Adineta vaga

A. Houtain, A. Derzelle, M. Lliros, B. Hespeels, E. Nicolas, P. Simion, J. Virgo, T. Lenormand, B. Hallet, K. Van Doninck

This study identifies a novel transgenerational DNA repair mechanism in the asexual bdelloid rotifer Adineta vaga that uses meiotic recombination to repair fragmented chromosomes across generations.

bioRxiv · Jan 25, 2024 · PreprintEvolutionary Biology

Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

C. Ogier, A. M. Charles Solomon, Z. Lu, L. Recoules, A. Klochkova, L. Gabitova-Cornell, B. Bayarmagnai, D. Restifo, A. Surumbayeva, D. B. Vendramini-Costa, A. Deneka, R. Francescone, A. C. Lilly, A. Sipman, J. C. Gardiner, , I. Astsaturov

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

Substantial genetic mixing among sexual and androgenetic lineages within the clam genus Corbicula

M. Vastrade, E. Etoundi, T. Bournonville, M. Colinet, N. Debortoli, S. M. Hedtke, E. Nicolas, L.-M. Pigneur, J. Virgo, J.-F. Flot, J. Marescaux, K. Van Doninck

The paper investigates genetic mixing in Corbicula clams, finding substantial allele sharing across sexual and androgenetic lineages, suggesting recent biogeographic origins and hybridization events.

bioRxiv · Mar 18, 2022Evolutionary Biology

Homologous chromosomes in asexual rotifer Adineta vaga suggest automixis

P. Simion, J. Narayan, A. Houtain, A. Derzelle, L. Baudry, E. Nicolas, M. Cariou, N. Guiglielmoni, D. Kozlowski, F. R. Gaudray, M. Terwagne, J. Virgo, B. Noel, P. Wincker, E. G. Danchin, , K. Van Doninck

This study presents a high-quality chromosome-scale genome assembly of the asexual bdelloid rotifer Adineta vaga, revealing homologous chromosomes and evidence of recombination consistent with automixis.

bioRxiv · Jun 16, 2020Evolutionary Biology

TET1 and TDG suppress intestinal tumorigenesis by down regulating the inflammatory and immune response pathways

R. Tricarico, J. Madzo, G. Scher, S. Maegawa, J. Jelinek, C. Scher, W.-C. Chang, E. Nicolas, Y. Zhou, M. Slifker, K. Devarajan, K. Q. Cai, P. Nakajima, J. Xu, P. Mancuso, , A. Bellacosa

This study shows that TET1 and TDG reduce intestinal tumor formation by suppressing inflammatory and immune response pathways through DNA demethylation.

bioRxiv · Jun 21, 2019 · PreprintCancer Biology

Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer

L. G. Cornell, S. Peri, D. Restifo, A. Klochkova, T. R. Hartman, A. M. O'Reilly, R. Francescone, J. Franco-Barraza, N. Shah, E. Nicolas, E. A. Handorf, K. Q. Cai, A. Mazitova, I. Sloma, R. Chiaverelli, , I. Astsaturov

The paper shows that cholesterol deprivation activates TGFβ signaling, promoting basal differentiation in pancreatic cancer by stabilizing the TGFβ receptor.

bioRxiv · May 11, 2019 · PreprintCancer Biology

Conjugated linolenic fatty acids trigger ferroptosis in triple-negative breast cancer

A. Beatty, T. Singh, Y. Y. Tyurina, E. Nicolas, K. Maslar, Y. Zhou, K. Q. Cai, Y. Tan, S. Doll, M. Conrad, H. Bayır, V. E. Kagan, U. Rennefahrt, J. R. Peterson

This study identifies conjugated linolenic acids as ferroptosis inducers in triple-negative breast cancer and shows their anti-tumor effects in a xenograft model.

bioRxiv · Feb 20, 2019 · PreprintCancer Biology