A. Melamed

The impact of HTLV-1 expression on the 3D structure and expression of host chromatin

The paper investigates how HTLV-1 proviral transcription affects host chromatin structure and finds that it induces aberrant transcription but suppresses chromatin loop formation.

Time-course of host cell transcription during the HTLV-1 transcriptional burst

This study examines how HTLV-1 transcriptional bursts affect host transcription over time in infected T-cells, finding transient activation of pathways like NF-κB and clone-specific differences in cell cycle regulation.

Selective clonal persistence of human retroviruses in vivo: radial chromatin organization, integration site and host transcription

The paper identifies genomic features that determine the survival of HTLV-1 and HIV-1 clones in vivo, showing that radial chromatin organization, integration site, and host transcription influence clonal persistence.

The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis

This study shows HTLV-1 disrupts host chromatin structure and causes abnormal transcription patterns in cis.