Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer
A. Mello, T. Ngodup, Y. Lee, K. L. Donahue, J. Li, A. Rao, E. S. Carpenter, H. C. Crawford, M. Pasca di Magliano, K. E. Lee
This study shows hypoxia drives an inflammatory phenotype in pancreatic cancer-associated fibroblasts, promoting tumor IL1 expression and iCAF formation in hypoxic regions.
bioRxiv · May 5, 2022Cancer Biology